PFKM and cancer: Interestingly, PIM2 can also phosphorylate the glycolysis regulator PFKFB3 (6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3), overexpressed in many cancer cells, leading to activation of PFK1 (phosphofructokinase 1), the third enzyme of the glycolytic pathway [65].