ADAM17 and infection: In the present study, there was some overlap between the samples used for the GWAS of ADAM17 and the GWAS of COVID-19, which included cases of hospitalized COVID-19 patients that were either critically or moderately ill and cases from all reported SARS-CoV-2 infections (termed, respectively, critical COVID-19, hospitalized COVID-19 and SARS-CoV-2 reported infections; see Materials and Methods section).