The rs6128 genotypes distribution in three subgroups (healthy, IFG, DM2) had no significant differences, but participants without retinopathy were more likely to be minor allele homozygotes (TT; 5.7%) than those with retinopathy (p = 0.03). The rs6128 minor allele homozygotes had lower mean P-selectin plasma levels than major allele carriers (25.8 ng/mL vs. 34.5 ng/mL; p = 0.046). There were no significant associations with either retinopathy or P-selectin levels for rs6133 and rs3917779. The gene discussed is SELP; the disease is retinal disorder.