The largest number of genes related to the development of retinopathy is found on chromosome 1 (SELP, MTHFR, NVL, CRP), and 7 (IL-6, eNOS, AR, PAI-1), while most studies on the relationship between the development of retinopathy and polymorphism are focused on VEGF gene (chromosome 6), ACE (chromosome 17), and APOE (chromosome 19). The gene discussed is MTHFR; the disease is retinal disorder.