ACE and retinal disorder: The largest number of genes related to the development of retinopathy is found on chromosome 1 (SELP, MTHFR, NVL, CRP), and 7 (IL-6, eNOS, AR, PAI-1), while most studies on the relationship between the development of retinopathy and polymorphism are focused on VEGF gene (chromosome 6), ACE (chromosome 17), and APOE (chromosome 19).