It is hypothesized that in Alzheimer’s disease, neuronal cells produce more miR-146a, which decreases the levels of protein kinase 1 (ROCK1) and reduces the levels of phosphatase and tensin homolog phosphorylated (p-PTEN), preventing the dephosphorylation of the tau protein (p-tau). The gene discussed is PTEN; the disease is early-onset autosomal dominant Alzheimer disease.