The results suggest that the anti-cancer effect of HATMSC2-MVs is mainly contributed by delivery of molecules that induce cell cycle arrest and apoptosis (p21, tumor suppressor p53, executor caspase 3) and proapoptotic regulators (bad, BIM, Fas, FasL, p27, TRAIL-R1, TRAIL-R2). The gene discussed is TP53; the disease is cancer.