NOTCH1 and Alzheimer disease: Soluble amyloid-β (Aβ) oligomers are thought to play a key role in the pathogenesis of AD (Alzheimer’s disease), and melatonin, through its role in modulating a wide range of signaling pathways, including Notch1, may be a potential therapeutic agent for AD and possibly other age-related neurodegenerative diseases [14].