Additionally, we also explored the impact on acid ceramidase (encoded by ASAH1) that may catalyze the conversion of Gb3 into lyso-Gb3 [16,17,18], and GLA, which encodes alpha-galactosidase A, the enzyme which is defective in Fabry disease and whose lysosomal activity removes the galactose residues that had been added by Gb3 synthase. This evidence concerns the gene A4GALT and Fabry disease.