Following induction of DM, no differences were apparent between diabetic WT and diabetic Fabry mice in mean glycemia values over follow-up (WT-DM 434 ± 36 vs. Fabry-DM 417 ± 36 mg/dL, p-value = 0.75), insulin requirements (1.76 ± 0.33 vs. 1.60 ± 0.27 IU/day, p-value = 0.70) or mortality. This evidence concerns the gene INS and diabetes mellitus.