GLA and Fabry disease: Additionally, we also explored the impact on acid ceramidase (encoded by ASAH1) that may catalyze the conversion of Gb3 into lyso-Gb3 [16,17,18], and GLA, which encodes alpha-galactosidase A, the enzyme which is defective in Fabry disease and whose lysosomal activity removes the galactose residues that had been added by Gb3 synthase.