While certain mutations (e.g., DNMT3A, TET2, and ASXL1) are frequently observed in clonal hematopoiesis and seem to occur relatively early in leukemogenesis, others tend to emerge later during the progression of leukemia, they include mutations in FLT3, NRAS, and RUNX1 [51]. The gene discussed is RUNX1; the disease is leukemia.