Because PGC-1 α coordinates mitochondrial biogenesis and function, the suppressed PGC-1a expression in the liver is expected to lead to impaired mitochondrial function and biogenesis, leading to decreased fatty acid oxidation and the accumulation of triglyceride development of non-alcoholic fatty liver diseases (NAFLDs). The gene discussed is PPARGC1A; the disease is metabolic dysfunction-associated steatotic liver disease.