DNMT1 and schizophrenia: DNA methyltransferase 1 (DNMT1), activating compounds such as resveratrol, genistein, curcumin, and other natural polyphenols that stimulate the activity of DNA methyl transferases, have been shown to be effective for rectifying under methylation in some cell types, but these have yet to be trialled for schizophrenia [91].