The homozygous polymorphism form of this MTHFR C677T gene is the MTHFR 677 TT genotype, which has been implicated in multiple pathological conditions, including pre-eclampsia, folate deficient fetal neural tube defects, colon cancer, and depression and schizophrenia in adults [10]. The gene discussed is MTHFR; the disease is malignant colon neoplasm.