Therefore, GH is considered the early phase of the pathogenetic process that leads to chronic kidney disease (CKD), which is conversely defined by a reduced GFR (<60 mL/min/1.73 m [2]) and/or markers of kidney damage, indicated by moderately increased albuminuria (albumin-to-creatinine ratio (UACR) 30–300 mg/g), severely increased UACR (>300 mg/g) or nephrotic-range proteinuria (UACR > 2200 mg/g). The gene discussed is ALB; the disease is chronic kidney disease.