AIF1 and neuropathic pain: To further confirm the switch from an M1 to an M2 phenotype, we also investigated the influence of Iba1 silencing on the mRNA level of key pro-inflammatory cytokines IL-6, TNF-α and IL-1β, which were reportedly expressed in non-neuronal cells of the DRG [15,26,50] and have been previously implicated in neuropathic pain [6,15] (Figure 6; see also Supplemental Table S6 for numerical values of mRNA levels and for complete comparisons between conditions).