Stimulation with TNF-α/IFN-γ induces the production of pruritic cytokines and chemotactic chemokines in keratinocytes such as TSLP, IL-31, CCL17/TARC, and CCL22/MDC, further expanding skin inflammation with the recruitment of major T cell lineage, Th2 cells, resulting in epidermal damage [31,32,33]. This evidence concerns the gene CCL22 and dermatitis.