Ke MJ et al. have reported that the knockdown of DLGAP5 results in a significant increase in the levels of p53, p-p53, and p21 proteins, suggesting that the p53 pathway is activated in pancreatic cancer cells, which might suppress the malignant phenotype of pancreatic cancer cells [15]. The gene discussed is DLGAP5; the disease is familial pancreatic carcinoma.