Gao et al. demonstrated that the overexpression of CAPON-S inhibits the proliferation of glioma cells, arrests the glioma cell cycle in G1 phase, and inhibits the serine/threonine kinase (Akt)-S6 ribosomal protein cell signaling pathway (Akt-S6 cell signaling pathway). Here, AKT1 is linked to central nervous system cancer.