PAD4, an enzyme taking part in chromatin decondensation during NETosis cascade and citrullinated histones, were markedly elevated in both T1DM and T2DM, which implicated poor wound healing in both mice and human, and interestingly, PAD4 inhibition with Cl amidine and application of DNase restore the wound healing [173,174]. The gene discussed is PADI4; the disease is type 2 diabetes mellitus.