Excessive production of cytokines termed cytokine storm is the hallmark in the pathogenesis of COVID-19 with augmented plasma levels of CCL 2, IFNγ, IFNγ-inducible protein 10, G-CSF, CCL3, IL-1β, IL-2, IL-6, IL-7, IL-8, IL-10, IL-17, and TNF-α, leading to subsequent severe consequences like ALI, ARDS, pulmonary thrombosis, and MODS [142,143,144,145,146]. The gene discussed is TNF; the disease is acute respiratory distress syndrome.