The expression of genes coding for the TLDc domain-containing proteins OXR1, TLDC1, NCOA7, TBC1D24, and C20ORF118 was evaluated in peripheral blood mononuclear cells (PBMCs) isolated from children with ASD and from their neurotypically developing (NTD) counterparts using quantitative real-time PCR (qPCR). This evidence concerns the gene OXR1 and neural tube defect.