Aloe-emodin was proposed as one of the components of aloe vera extract responsible for its cytotoxic activity for the MCF-7 human BC cell line due to its particularly strong calculated binding affinity toward ERα (−8.8 kcal/mol) as compared to the standard drug tamoxifen (−6.4 kcal/mol) [60]. Here, ESR1 is linked to breast cancer.