Emodin also attenuated cancer cell metastasis and angiogenesis in vitro via MMPs and vascular endothelial growth factor receptor 2 (VEGFR2) inhibition, which may be associated with the downregulation of the Runx2 [46], a transcription factor which is one of the members in the Runx gene family encoding proteins homologous to Drosophila Runt and a potential target for inhibition of metastatic growth of BC cells [47]. Here, RUNX2 is linked to breast cancer.