TIMP1 and diabetic foot: Collagenases are enzymes from the MMP family (MMP-1, -8, -13) that are naturally inhibited by TIMP-1 and -2 [35,36]; Lobmann reported MMP-1 and -8 expression was sixty-five fold and two-fold higher, respectively, in biopsies taken from diabetic foot ulcers compared to acute traumatic wounds in non-diabetic patients, highlighting the importance of TIMPs in the inhibition of collagenases [37].