In this observational study we identified five abundant proteins (p ≤ 0.05) differentially expressed between sepsis patients with and without SAD, including paraoxonase-1 (PON1), immunoglobulin (IgHV3), complement subcomponent (C1QC), thrombospondin 1 (THBS1), and full fibrinogen gamma chain (FGG), in plasma EVs. This evidence concerns the gene FGG and Sepsis.