C3 and hyperinsulinemic hypoglycemia, familial, 4: Finally, we analyzed the alteration in the concentration of GI hormones in the mid colon of Urd- and AEtLP-treated C3 KO mice to determine whether the effects of Urd and AEtLP in improving the ENS function during C3-deficiency-induced constipation were accompanied by an alteration in the regulation of the GI hormones.