For this, several constipation-related parameters, including parameters associated with stools and evacuation, GI transit, histopathological features of the mid colon, mucin secretion ability, water retention capacity, ENS function, and GI hormone secretion, were analyzed in 16-week-old C3 KO mice after administration of Urd and AEtLP. Here, MUC5AC is linked to constipation disorder.