RHOJ and cancer: Among the components of the signaling landscape that accompanies the Gαq-Q209L/PDZ-RhoGEF/RhoJ signaling axis, those whose names are underlined in Figure 6B have been revealed as vulnerabilities in various cancer cell lines (Figure 6C), due to synthetic lethality strategies analyzed at the cancer dependency map datasets (https://depmap.org/portal/; accessed on 12 October 2023) [27].