For instance, the endothelin type A receptor, encoded by EDNRA, drives ovarian cancer progression by promoting invadopodia formation through a β-arrestin/PDZ-RhoGEF-mediated mechanism [31], promotes colorectal cancer progression [32], and is associated with metastasis in patients with advanced bladder cancer [33]. The gene discussed is EDNRA; the disease is urinary bladder carcinoma.