We postulate that GTPase-deficient Gαq enables PDZ-RhoGEF to activate RhoJ, a member of the Cdc42 subfamily controlling endosomal trafficking of α5β1 integrins [14,15,16] and focal adhesion dynamics [17], as well as cancer progression via tumor-induced angiogenesis, metastatic dissemination of cancer cells, and drug resistance [14,15,16,18]. The gene discussed is RHOJ; the disease is cancer.