However, Venegas-Moreano et al. [102] described a negative correlation between SSTR1 and tumor dimension and a positive connection with responsiveness to medical treatment in acromegalic patients, suggesting a multimodal behavior of SSTR1 when it comes to different PitNET subtypes (similar to what happens with SSTR2 and ACTH-PitNETs as mentioned above). This evidence concerns the gene POMC and neoplasm.