Dai et al. [199] associated Gal-3 with PitNETs invasiveness, tumor dimension, and pre-surgical PRL levels in PRL-secreting tumors, but they went further to demonstrate that in vitro MMQ cells transfected with Gal-3 siRNA showed lower concentrations of MMP2 and MMP9 and inferior migration capabilities, while also increasing the apoptosis rate. The gene discussed is PRL; the disease is neoplasm.