Chemokines, such as CXCL8 (or interleukin (IL)-8), CCL2, CCL3, and CCL4, are secreted by pituitary tumors and non-tumor cells, such as macrophages, lymphocytes, or fibroblasts, and modulate the microenvironment composition [20,25]. The gene discussed is CXCL8; the disease is pituitary tumor.