In this study, contrary to the observed associations between CHIP and SVT in the study of idiopathic SVT by Magaz et al., HMR features such as bi-allelic TP53 loss, ASXL1 and CSMD1 mutations were predictive of leukemic evolution, but neither were associated with SVT recurrence nor with thrombo-hemorrhagic complications. Here, ASXL1 is linked to Supraventricular tachycardia.