Despite these limitations, our study provides initial evidence that the rs1771575 eQTL, located in an intergenic regulatory region, is the sole FCGR polymorphic variant analyzed significantly associated with blood-stage parasitemia in children living in Burkina Faso, regardless of age and the presence of FCGR2A/FCGR2B coding allelic variants previously associated with protective immunity against malaria. The gene discussed is FCGR2A; the disease is malaria.