To understand the mechanistic and clonal link between skin-primed T cells and clone expansion in the peripheral blood of psoriatic disease patients or in the synovial fluid of PsA individuals, an imiquimod-induced psoriasis-like inflammation model in K5-mOVA.tg mice expressing ovalbumin on the membrane of keratinocytes adoptively transferred with ovalbumin-specific OT-I.tg naïve CD8+ T cells was used to add the antigen-specific T cell component to the model of psoriasis-like inflammation [98]. Here, CD8A is linked to psoriasis.