TP53 and myocardial ischemia: Expanding on a previous study performed by single-cell RNA sequencing in ECs submitted to permanent myocardial ischemia demonstrated the implication of the intrinsic signaling pathway via bax and trp53 upregulation [18], our data showed heightened mRNA expression of the genes involved in intrinsic (n = 2) and extrinsic (n = 13) signaling pathways (Figure 3).