TNF and ischemia: Table 3 shows a total of 16 genes included in the BPs underlying the endothelial cell apoptotic process (GO: 0072577) and regulation of endothelial cell apoptotic process (GO: 200035), which displays increased mRNA expression during the initial stages of ischemia (days 1–3). Based on our results, serpine1 and thbs1 exhibited the highest transcriptomic changes at very acute phases following MI. Indeed, tnf, angptl4, tert, and il10 also displayed a significant increase in mRNA levels a few hours after ischemia onset (Table 3).