BMI1 and breast cancer: Interestingly, when a more accurate and stringent analysis was performed on the regulated target genes of these two candidate miRNAs, Mienturnet analysis followed by MetaCore process networks revealed the presence of important central hubs, including the transcriptional factors SP1 (specificity protein 1), RXRA (retinoid X receptor alpha), and BMI-1 (polycomb ring finger proto-oncogene) and the epidermal growth factor receptor kinase EGFR, with multiple roles in breast cancer development and progression [79,80,81,82].