In addition, the PSEN1−/APOE4+ group showed the inverse result (Figure 2), suggesting that the variants in the PSEN1 and APOEε4 alleles have a different interaction compared with EOAD patients with whom the genetic cause is unknown, as it has been shown that patients with APOEε4 show greater cognitive decline compared to patients without this allele in LOAD [32,33,34]. This evidence concerns the gene PSEN1 and Mental deterioration.