TPM1 and channelopathy: One such disease is myotonic dystrophy type I (MD1), known as Steinert disease, associated with a DMPK gene defect and channelopathy caused by mutations in genes associated with cardiac function (i.e., TNNT, TNNT2, TTN, TPM1, SYNE1, MTMR1, NEBL, and TPM1), including CACNA1A and CACNA1H [41].