To date, two genetic diseases associated with mutations in ventricular RyR2 have been described: catecholaminergic polymorphic ventricular tachycardia (CPVT), or familial polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) type 2 [83]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.