In the human prostate cancer PC-3 spheroid model that expressed KCa1.1 at a low level (less than 0.001 a.u.), the PAX treatment did not affect the expression level of CYP3A4 transcripts (n = 4 for each, p > 0.05) (Supplementary Figure S2G). This evidence concerns the gene CYP3A4 and prostate cancer.