Incidentally, the same gene was cloned from a library of the human prostate cancer cell line PC-3M and described as a tumor suppressor (named Tumor Metastasis Suppressor Gene 1 (TMSG1)) because its expression was lower in the metastatic prostate cancer cell line PC-3M-1E8 compared to the non-metastatic PC-3M-2B4 [8,16]. This evidence concerns the gene CERS2 and Familial prostate cancer.