CERS2 and ovarian cancer: For ovarian cancer, it has been observed that CERS2-negative tumors show significant association with longer disease-free survival and overall survival in cancer patients, and experimentally, CERS2 overexpression in the 3AO ovarian cancer cell line promoted migration, invasion, and metastasis abilities, while CERS2 knockdown in ES-2 and NIH:OVCAR-3 ovarian cancer cell lines had the opposite effects [11].