Regarding the possible role of circulating CERS2 in EVs as a biomarker, there are several reports on the presence of the protein and mRNA in EV preparations registered in Vesiclepedia archives (http://microvesicles.org/ accessed 6 June of 2023) isolated from different tumor tissues such as glioblastoma, colorectal, breast, or brain cancer. Here, CERS2 is linked to neoplasm.