To investigate the function of UBE2C on the proliferation and migration of cancer cells, we first constructed the NCI-H460, HepG2, and MCF7 cancer cell lines with the sSknockdown of UBE2C (namely Lv-NCI-H460, Lv-HepG2, and Lv-MCF7) whose expression level of the UBE2C protein (top to bottom: p = 0.0040, 0.0123, 0.0252) and copy number of the UBE2C gene (top to bottom: p = 0.0039, <0.0001, 0.0038) were significantly reduced (Figure 2A,B). Here, UBE2C is linked to cancer.