Six of the eleven were down-regulated in patients with HCC, including matrix metalloproteinase-9 (MMP9), insulin-like growth factor-binding protein complex acid labile subunit (IGFALS), immunoglobulin lambda-like polypeptide 5 (IGLL5), sex hormone-binding globulin (SHBG), insulin-like growth factor-binding protein 3 (IGFBP3), and lactotransferrin (LTF). This evidence concerns the gene IGFALS and hepatocellular carcinoma.