The study of Lee et al., performed by liquid chromatography–tandem mass spectrometry and label-free quantification in plasma from BPD and MDD subjects, took into account the effects of medication over protein expression (antipsychotics, mood stabilizers, antidepressants, or benzodiazepines) and demonstrated that Apo D expression was not affected for any of the antipsychotic drugs. The gene discussed is APOD; the disease is major depressive disorder.