RYR2 and paroxysmal familial ventricular fibrillation: Mutations in RyR2 (over 150 have been reported up to date) have been associated with life-threatening arrhythmogenic disorders, such as catecholaminergic polymorphic ventricular tachycardia (CPVT), idiopathic ventricular fibrillation (IVF) and arrhythmogenic right ventricular dysplasia type 2 that can lead to sudden cardiac death [4,5,6,7,8,9].