Given that the drug-resistant prostate cancer cell line LN-FLU exhibited stem cell-like characteristics and the upregulated expressions of pluripotent genes such as OCT4, as well as efflux transporters like ABCB1A, we examined the expressions of the stem cell markers Oct4 and ABCB1A in the prostate cancer patient samples. This evidence concerns the gene POU5F1 and prostate cancer.