In analysis of targeted sequencing data from matched primary tumours and metastases, it was shown that all cases had at least one mutation in common between the primary tumour and metastases, along with unique mutations present either only in the primary tumour (e.g., TBX3 in GM06BR) or only in the metastases (e.g., RB1, TP53 in GM74LO) [94]. The gene discussed is RB1; the disease is neoplasm.