KALRN and schizophrenia: Recently, several variants of RhoA-associated GAPs, including ARHGAP10 [48], ARHGAP18 [49,50,51], and p250GAP [52], and GEFs such as KALRN [53,54,55,56] and ARHGEF11 [57], were reported to be significantly associated with the development of schizophrenia.