Chronically elevated IGF-1, and/or increased IGF-1 bioavailability and sensitivity, receptor expression, and amount of Ras protein prenylation [51] are strongly implicated in neoplasia and ageing [48,53,54,55,56], whilst IGF-1 knockdown within in vivo models show improved longevity [56,57]. This evidence concerns the gene IGF1 and neoplasm.