In this metabolic phenotype 1 context [8], an infrequent one-time bolus insulin secretion does not inhibit gluconeogenesis and glycogenolysis; this may incorrectly be interpreted as hepatic insulin resistance, as is the case for hyperinsulinaemic T2DM (stage-3 metabolic phenotype 3) individuals [8]. This evidence concerns the gene INS and type 2 diabetes mellitus.