Moreover, a neurodegeneration-specific gene expression signature of acutely isolated microglia from an ALS mouse model has revealed co-regulated genes in the lysosome pathway, which include several cathepsins (A, B, D, L, S, X, and E), a host of lysosome enzymes (HexA), membrane markers (Cd68, Cd63, and Lamp1), and components of lysosomal ATPase (Atp6v0d1) [207]. Here, CTSS is linked to amyotrophic lateral sclerosis.