In addition, Boutahar et al. evaluated the effect of oxidative or excitotoxic stress on the transcriptional profile of ALS-linked mutant SOD1-cultured neurones and observed that both the ubiquitin-proteasome and endolysosomal systems are upregulated in transgenic neuron cultures [203]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.