CTSB and amyotrophic lateral sclerosis: cDNA microarray analysis of post-mortem spinal cord specimens from four patients with sporadic ALS compared to four age-matched non-neurological controls revealed 60 differentially expressed genes, including an increase in the expressions of cathepsins B and D, apolipoprotein E, epidermal growth factor receptor, ferritin, and lysosomal trafficking regulator [202].