HSPB1 and amyotrophic lateral sclerosis: Fukada et al. analysed gene expressions in the spinal cord of SOD1 (L126delTT) Tg mice using a cDNA microarray and identified four genes (Crym, Hspb1/Hsp27, CtsH, and Paip1) potentially related to the pathogenesis of familial ALS, including the progression of reactive astrocytes and the inflammatory response of microglial cells.