GNA11 and neoplasm: UM and CM carry different tumor initiating-mutations, GNAQ, GNA11, CYSLTR2, PLCB4 in UM and BRAF, NRAS, NF1 in CM, and show a different frequency of mutations (mutational burden), very high for CM (>10 mutations per megabase [6]) and very low for UM (0.5 mutations per megabase [7]).