RUNX2 and Fabry disease: Consistent with these views, BMSCs derived from a FD patient or stimulated via PTHrP or WNT family member 3A (WNT3A) displayed an extreme prominence of early osteogenic markers, i.e., the bone matrix proteins COL1 and ALP and the transcription factors RUNX2 and OSX, but when overstimulated with high levels of PTHrP or WNT3A, a reduced maturation status was observed [62,63].