A number of biomarkers has been proposed for non-invasive diagnosis of endometriosis, i.e., cancer antigen-125 (CA-125), cancer antigen-19-9 (CA-19-9), interleukin-6 (IL-6), anti-endometrial antibodies (AEA); however, all of them are associated with advanced endometriosis and not applicable to the early stages of the disease [3,10]. Here, MUC16 is linked to endometriosis.