We chose cell lines that represent a range of hallmark features of neuroblastoma: MYCN-amplified (SK-N-BE(2)C) vs. non-amplified (SH-EP + SK-N-AS), as well as cell lines conforming to the adrenergic (SK-N-BE(2)C), mixed (SK-N-AS) and mesenchymal (SH-EP) super-enhancer classification [26,27,28]. Here, MYCN is linked to neuroblastoma.