MYC and neuroblastoma: Similar to TH-MYCN ganglia, MGS expression also correlated with tumors that had a high MYC or MYCN transcriptional activity (Figure 3D) and MGS expression was significantly higher in clinical categories of poor prognosis for MYCN amplification, metastasis (International neuroblastoma staging system—INSS4) and older age (>18 months) compared with their lower risk counterparts (Figure 3E).