MYCN and neuroblastoma: To investigate the functional role of mitotic dysregulation in pre-malignant neuroblasts, we treated TH-MYCN+/+ mice prophylactically with either barasertib, a small molecule inhibitor of AURKB (regulates alignment and segregation of chromosomes during mitosis) or vincristine, standard antimitotic chemotherapy against neuroblastoma that inhibits microtubule formation in the mitotic spindle [1,20].