CRP and cholangiocarcinoma: As was concluded by the machine-learning-based model, fibrinogen, ferritin light chain protein (FRIL), and C-reactive protein (CRP), all with/without the combination of carbohydrate antigen 19-9 (CA19-9), for the diagnosis of local PSC-associated CCA versus PSC alone, had an AUC of 0.947, which also enhanced the value of CA-19-9 as a biomarker alone.