ORM1 and cholangiocarcinoma: Based on the aforementioned, all these EV cargoes can potentially help in the differential diagnosis between CCA cases, from healthy individuals to individuals with other malignancies or inflammatory diseases [67,105], whereas it has been also demonstrated that the presence of overexpressed EV cargoes, such as CRP, vitamin D-binding protein (VTDB), FIBG, and A1AG1, can be potentially utilized as differential diagnostic biomarkers between iCCA and HCC [67,105].