Neutrophils also present a dual role, primarily as suppressors of tumor growth, and, later, act as promoters (tumor-associated neutrophils (TANs)) of neoangiogenesis and local invasion via releasing VEGF and MMP-9, respectively [52], while another source of several types of metalloproteinases that also lead to ECM modification is adipocytes [53]. The gene discussed is MMP9; the disease is neoplasm.