Finally, they reported, based on their multi-parametric analysis, that EVs can be also utilized as biomarkers for CCA prognosis, with PF4V, alpha-actinin-1(ACTN1), and MYC target 1 (MYCT1) proteins being related to a good prognosis and survival, and complement factor I (CFAI), cartilage oligomeric matrix protein (COMP), and G protein subunit i2 (GNAI2) with poor ones [104]. Here, COMP is linked to cholangiocarcinoma.