SGPL1 and glomerulosclerosis: Consistent with these findings, Periodic acid Schiff-stained fixed kidney sections of untreated Sgpl1 KO mice exhibited signs of glomerulosclerosis at 26 days of life, including mesangial expansion, with a mean of 18% sclerotic glomeruli compared to no detectible sclerotic glomeruli in either WT or AAV-SPL 2.0-treated mouse kidneys (Figure 4B, left panel).