The ability of bergapten to generate apoptotic responses through the up-regulation of not only caspase-9 but also caspase-8 has, indeed, been revealed in MCF-7 (a human breast cancer cell line with estrogen, progesterone, and glucocorticoid receptors) and SKBR-3 cells (a human breast cancer cell line) [35], thus highlighting the possible importance of these two death tracks in its action. This evidence concerns the gene CASP8 and breast cancer.