TIMP2 and breast cancer: In agreement with our observation, Zhang et al. [63] revealed that bergapten-containing products derived from Ficus carica were able to impair the migration ability of the breast cancer cell line MDA-MB-231 by modulating the expression of crucial factors in the invasion process, such as MMP2 (metalloproteinase 2), TIMP-1, and TIMP-2 (tissue inhibitors of metalloproteinases 1 and 2).