PTEN and breast carcinoma: In breast cancer models (MCF-7 and ZR-75), bergapten was shown to exert an anti-survival effect through the process of autophagy, as evidenced via the PTEN-dependent up-regulation (PTEN—dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine-, and threonine-phosphorylated proteins) of its key protein markers, i.e., Beclin1 (Bcl-2 interacting protein), PI3KIII (phosphatidylinositol 3-kinase), UVRAG (UV radiation resistance-associated gene protein), and AMBRA (actin binding Rho-activated protein).