Third, Tiliroside treatment markedly blocked LPS-stimulated renal ACE activity, urinary renin activity, and urinary prorenin/renin excretion but abolished LPS-reduced renal ACE2 activity, resulting in decreased urinary Ang II excretion and increased urinary Ang1-7 excretion, accompanied with the improved AKI. Here, ACE2 is linked to acute kidney injury.