AANAT and microphthalmia: Shim and Tanaka demonstrated that TRF promotes circadian synchronization regardless of exposure to light: rats with hereditary microphthalmia (blind) maintained the synchronization of their circadian phases when submitted to TRF (6 h/day), showing a peak of enzymatic activity (serotonin N-acetyltransferase, which catalyzes the production of melatonin from pineal serotonin) during the feeding period [41].